Bastin Research Group

Undergraduates in my lab work on a variety of research projects in the fields of biochemistry and organic chemistry.

Biocompatibility of a nanoporous alumina-based hemodialysis membrane.  In collaboration with Prof. Huang in Mechanical Engineering, Prof. Morris in Biology, and William Van Geetruyden of EMV Technologies, we are studying the biocompatibility of an alumina hemodialysis membrane.  We are investigating the affect of the membrane on a variety of biologically important molecules during dialysis.  We are also studying possible degradation of the membrane during dialysis.

The Isolation and Characterization of Parvalbumin Isoforms from Fish Muscle.  In collaboration with Prof. Coughlin in Biology, we are studying the role of the protein parvalbumin in muscle relaxation by relating the calcium and magnesium binding properties of the parvalbumin isoforms to protein structure and physiology experiments (performed by Prof. Coughlin’s research group).

The Role of Proteins in the Development of Zebra and Quagga Mussel Shells.  We are investigating the role proteins play in the growth of zebra and quagga mussel shells by isolating and characterizing shell proteins the organisms.  It is our hope to use this knowledge to design a method to inhibit zebra and quagga mussel shell growth in order to control the massive population growth of these evasive species in the U.S.

Inhibition of Calcium Sulfate Crystals using Phosphonic Acids.  We are designing and synthesizing potential inhibitors of calcium sulfate crystal growth in order to reduce scaling on ocean liners and pipes.
 Comparison of Proteins Isolated from the Haliotis Family of Mollusks.  We are looking at the role proteins play in the growth of abalone shells by isolating and characterizing shell proteins.  We hope these studies will lead to a better understanding of the interactions between proteins and crystals during biological processes such as shell and bone growth.

The Isolation, Purification, and Characterization of Antifreeze Proteins from Rainbow and Sea Smelt.  We are looking at the mechanism by which proteins known as antifreeze proteins prohibit ice crystal growth in fish at sub-freezing temperatures.