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Orkoulas_Headshot

My research interests are in the area of mathematical modeling, simulation, optimization, and control of multiscale physico-chemical process systems and in the area of thermodynamic modeling and molecular simulation (Monte Carlo, molecular dynamics and kinetic Monte Carlo) of complex fluids.

My specific research areas include: modeling and simulation of multiscale process systems Detailed process description using conservation laws and stochastic model construction Parameter estimation from microscopic/mesoscopic simulations; model-based control and optimization of multiscale process systems Model reduction, coarse-graining, and predictive control of distributed parameter systems Dynamic optimization over multiple length scales; molecular simulation of complex fluids Monte Carlo, molecular dynamics, and kinetic Monte Carlo methods Development and optimization techniques for parallel codes using domain decomposition.

Sachin P. Patil

My long-term research interest and goal is to establish an active, externally-funded research program at Widener University with the motto of "Better health through discovery, de novo design, and effective delivery of novel drugs." Despite tremendous medical advances, we still face many health challenges for which there is no effective cure. The age-associated disorders like cancer and Alzheimer's disease are two of the most notorious examples of such devastating diseases.

Cancer is still the second leading cause of death in the U.S. Similarly, there are currently 5.2 million Alzheimer's disease patients in the U.S., and the numbers are expected to rise significantly owing to the aging population of baby boomers and lack of any effective cure. In this context, the primary aim of my research work is to unravel the molecular mechanisms underlying these diseases and use these novel mechanistic understandings to discover and design effective therapeutics against these traditionally-challenging diseases:

Alzheimer's Disease – Apolipoprotein E (ApoE) is one of the most significant risk factors for late-onset or sporadic Alzheimer's disease. ApoE has been shown to be critical in clearing the harmful ApoE deposits from the brain and its ability to do that depends upon its lipidation status. Therefore, there is a growing interest in understanding the underlying mechanisms involved in ApoE lipidation and using these mechanistic understandings to discover drugs to enhance ApoE lipidation status.
My laboratory is investigating potential involvement of abnormal glucose metabolism in poor ApoE lipidation.

Cancer – The p53 protein plays a central role in protecting cells against carcinogenesis. It is inhibited in 50% of human tumors, however, by interaction with the oncogenic MDM2 protein. Therefore, blocking the p53-binding pocket on MDM2 protein by small-molecule drugs, leading to activation of the tumor suppressor p53 protein presents a fundamentally novel strategy against several types of cancers. In this regard, my laboratory is involved in discovery and design of novel molecules that can mimic the p53 structural features involved in binding to the MDM2 pocket with the ultimate aim of blocking p53-MDM2 interaction.

Sachin P. Patil

My long-term research interest and goal is to establish an active, externally-funded research program at Widener University with the motto of "Better health through discovery, de novo design, and effective delivery of novel drugs." Despite tremendous medical advances, we still face many health challenges for which there is no effective cure. The age-associated disorders like cancer and Alzheimer's disease are two of the most notorious examples of such devastating diseases.

Cancer is still the second leading cause of death in the U.S. Similarly, there are currently 5.2 million Alzheimer's disease patients in the U.S., and the numbers are expected to rise significantly owing to the aging population of baby boomers and lack of any effective cure. In this context, the primary aim of my research work is to unravel the molecular mechanisms underlying these diseases and use these novel mechanistic understandings to discover and design effective therapeutics against these traditionally-challenging diseases:

Alzheimer's Disease – Apolipoprotein E (ApoE) is one of the most significant risk factors for late-onset or sporadic Alzheimer's disease. ApoE has been shown to be critical in clearing the harmful ApoE deposits from the brain and its ability to do that depends upon its lipidation status. Therefore, there is a growing interest in understanding the underlying mechanisms involved in ApoE lipidation and using these mechanistic understandings to discover drugs to enhance ApoE lipidation status.
My laboratory is investigating potential involvement of abnormal glucose metabolism in poor ApoE lipidation.

Cancer – The p53 protein plays a central role in protecting cells against carcinogenesis. It is inhibited in 50% of human tumors, however, by interaction with the oncogenic MDM2 protein. Therefore, blocking the p53-binding pocket on MDM2 protein by small-molecule drugs, leading to activation of the tumor suppressor p53 protein presents a fundamentally novel strategy against several types of cancers. In this regard, my laboratory is involved in discovery and design of novel molecules that can mimic the p53 structural features involved in binding to the MDM2 pocket with the ultimate aim of blocking p53-MDM2 interaction.

Dipendu Saha

Dipendu Saha

Chair of Chemical Engineering

Dr. Saha’s primary research interest lies with novel and sustainable materials design with broader applications in gas separation, water purification, precious metal recovery and chemical sensing. Currently, he is involved with carbon-based synthetic nanoporous materials, visible light-activated photocatalysts and plasmonic systems.