Catherine Safran, PhD

  • Assistant Professor

Programs I Teach

Education

  • PhD,¬†Developmental Biology (1994)
    University of Strasbourg (France)

About Me

I use my passion for life sciences and longstanding experience with muscular-skeletal research to introduce students to important concepts in field as various as evolution, plant & animal physiology, and environmental sciences.

My instructional strengths include emphasis on student engagement in the classroom, continuous evaluation of student learning progress, and special attention to student equity and well-being.

Research Interests

My research interest includes the study of mechanisms involved in mineralized tissue growth and repair. I am currently working in collaboration with Dr. Liyun Wang (University of Delaware, Department of Mechanical Engineering) to elucidate the role of the pericellular matrix in the bone response to load.

Publications

  • Perlecan/Hspg2-Deficient Mouse Mutant Reveals Regulatory Network of Genes associated with Bone Response to Load. Pei S., Parthasarathy S., Parajuli A., Wei S., Lu X.L., Farach-Carson M.C., Kirn-Safran C.B., Wang L. (manuscript in preparation, 2019).
  • Srinivasan P.P., Parajuli A., Price C., Wang L., Duncan R.L., Kirn-Safran C.B. Inhibition of T-Type Voltage Sensitive Calcium Channel Impairs Osteoblast Response to Mechanical Stress and Prevents Load-induced OA in Mice. PLoS One. 2015 26;10:e0127290
  • Lowe D.A., Lepori-Bui N., Fomin P.V., Sloofman L.G., Zhou X., Farach-Carson M.C., Wang L., and Kirn-Safran C.B. Deficiency in perlecan/HSPG2 Secretion Enhances Osteogenesis and Increases Bone Fragility in Adult Mice. Calcif.Tissue Int. & Musculosk. Res. 2014, 95:29-38

Professional Affiliations & Memberships

Human Anatomy and Physiology Society

Awards

  • Investigator on NIH R01-AR054385: "Mechanosensing in the Bone Lacunar-Canalicular System" (2015-2020)
  • Fellow of the Northeast Summer Institute on Scientific Teaching, University of Connecticut (2017)