Catherine Safran Profile Image

Catherine Safran, PhD

  • Assistant Teaching Professor
Media Expertise:
  • International Relations
  • Education
  • Science & Environment
  • Health Sciences

Affiliated Programs


  • PhD, Developmental Biology (1994)
    University of Strasbourg (France)

About Me

I use my passion for life sciences and longstanding experience with muscular-skeletal research to introduce students to important concepts in field as various as evolution, plant & animal physiology, and environmental sciences.

My instructional strengths include emphasis on student engagement in the classroom, continuous evaluation of student learning progress, and special attention to student equity and well-being.

Research Interests

My research interest includes the study of mechanisms involved in mineralized tissue growth and repair. I am currently working in collaboration with Dr. Liyun Wang (University of Delaware, Department of Mechanical Engineering) to elucidate the role of the pericellular matrix in the bone response to load.

Media Expertise

  • Preclinical models of bone & joint diseases 
  • Developmental biology of mineralized tissues
  • Cytomechanics and cell signaling 
  • Scientific teaching for pre-health professions


  • Trabecular Bone Deficit and Enhanced Anabolic Response to Re-Ambulation after Disuse in Perlecan-Deficient Skeleton. Parajuli A, Pei S, Zhao H, Martinez JR, Lu XL, Liu XS, Farach-Carson MC, Kirn-Safran CB, Wang L. Biomolecules. 2020, 10: pii: E198. 
  • Perlecan/Hspg2 deficiency impairs bone’s calcium signaling and associated transcriptome in response to mechanical loading. Pei S, Parthasarathy S, Parajuli A, Martinez J, Lv M, Jiang S, Wu D, Wei S, Lu XL, Farach-Carson MC, Kirn-Safran CB, Wang L. Bone. 2020, 131:115078. 
  • Srinivasan P.P., Parajuli A., Price C., Wang L., Duncan R.L., Kirn-Safran C.B. Inhibition of T-Type Voltage Sensitive Calcium Channel Impairs Osteoblast Response to Mechanical Stress and Prevents Load-induced OA in Mice. PLoS One. 2015 26;10:e0127290
  • Lowe D.A., Lepori-Bui N., Fomin P.V., Sloofman L.G., Zhou X., Farach-Carson M.C., Wang L., and Kirn-Safran C.B. Deficiency in perlecan/HSPG2 Secretion Enhances Osteogenesis and Increases Bone Fragility in Adult Mice. Calcif.Tissue Int. & Musculosk. Res. 2014, 95:29-38

Professional Affiliations & Memberships

Human Anatomy and Physiology Society


  • Improvement of teaching grant: “Enhance the Learning Experience of First-Year Students through Peer-Mentoring” (2020-2021)
  • Investigator on NIH R01-AR054385: "Mechanosensing in the Bone Lacunar-Canalicular System" (2015-2020)
  • Fellow of the Northeast Summer Institute on Scientific Teaching, University of Connecticut (2017)