Engineering Professor and Student Publish Promising Findings for Future Alzheimer's Disease Treatments
Sachin Patil, professor of chemical engineering and director of the NanoBio Lab, and Bella Kuehn '24 '25, a chemistry and chemical engineering double major in the 4+1 engineering program, published a paper in the journal Pharmaceuticals titled, “Discovery of Small Molecule Glycolytic Stimulants for Enhanced ApoE Lipidation in Alzheimer's Disease Cell Model."
The study established, for the first time, a possible link between two major Alzheimer’s disease (AD) causes, namely apolipoprotein E (ApoE), the most significant risk factor for AD, and abnormal glucose metabolism, which is an early and distinct feature of AD brain. The paper presented an integrated drug discovery approach leading to the identification of novel modulators of the glycolysis-ApoE nexus (Lonidamine, Phenformin, and Berberine), which may form the basis for the much-needed, disease-modifying therapies against the devastating disease like Alzheimer’s.