Engineering Professor, Interdisciplinary Student Team Publish Cancer Immunotherapy Discovery
Professor of Chemical Engineering Sachin Patil and a team of student-researchers published a paper in the journal Computational Biology and Chemistry titled, “Discovery of small-molecule PD-1/PD-L1 antagonists through combined virtual screening and experimental validation.” The paper presented an integrated drug discovery approach leading to identification of a novel PD-1/PD-L1 antagonist that may serve as a starting point for further optimization into potent, small-molecule cancer immunotherapies. The team included students from Widener's chemical engineering and computer science program, as well as Computer Science Professor Jeffrey Rufinus and technician John Stoddart. Michelle DiFrancesco '18, a chemical engineering graduate, served as the student team leader and study first author. She is currently continuing her cancer immunotherapy work at Bristol-Myers Squibb, a leading global biopharmaceutical company.
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