I am interested in understanding the inter-organ communication with relation to age-related systemic diseases. I aim to study organ-organ interactions through developing healthy and diseased 2-D and 3-D tissue models representing young vs. aged, and healthy vs. diseased phenotypes of different organs. My primary interest is to develop heart and liver tissues as these two major organs have many co-pathologies yet the effect of one organ's disease conditions on the other is not well-known.
Faculty Research Interests
My research interests are focused on the characterization and use of fiber-reinforced polymer (FRP) composites as a substitute for steel in reinforced concrete construction. My work encompasses both internal reinforcement for new construction and external reinforcement for strengthening and repair of existing structures, contributing to the development of an innovative technique for mechanically-fastening FRP laminates to the tension soffit of concrete beams.
As a fellow of the American Concrete Institute, I was recently appointed chairman of the ACI international committee that is tasked with developing code language for the design of structural concrete reinforced with FRP bars.
I have conducted diverse research studies which have given me understanding of various subjects and vast experience in a number of molecular, biochemical, cell biology, immunological and neurological techniques. I have extensive experience in cell and tissue culture techniques. My research interest is focused on application of stem cells (NSCs/MSCs) in understanding and treating different diseases of brain, lungs and heart. I also have interest in molecular and cell biology of microbes and malaria parasite. During my PhD., I investigated the translational status of a plastid-like organelle - apicoplast, known to be essential for the survival of Plasmodium falciparum.
My interest in biomaterials and tissue engineering was kickstarted during my first job as an engineer for Cook Biotech Inc., a company that manufactures medical devices made of small intestinal submucosa. Since then, I have studied mechanobiology, inflammation, tissue engineering and hyaluronan in tendon, fat, and liver. My current research interests include the mechanical behavior of diseased soft tissues and identifying the contributing cellular and extracellular matrix structures. I have particular interest in adipocytes and adipose tissue, the effects of fatty acids on mechanosensing and inflammation, and the development of cell- or tissue-engineering treatment strategies.
My research is focused on the following mission statement: "To develop new Atomic Force Microscopy experimental methods through the use of existing fundamental knowledge and through the discovery of new knowledge, in order to expand the capabilities of the instrument from imaging and characterization to also include reliable and repeatable fabrication of advanced materials."
My research interests are focused on the development and application of state-of-the-art thermal-fluid simulation tools for complex configurations and mission-critical facilities. My current interest is in the area of the fluid-structure interactions in micro-scaled air and underwater vehicles.
My research interests include numerical analysis and modeling and simulation dynamic and ballistic behavior of transparent and opaque ceramics; optimizing the properties of existing materials or the production of new materials with the aid of high energy fields (electric, electromagnetic, magnetic, acoustic); characterization of materials using various methods such as optical and electronic microscopy, nanohardness, and tensile testing
- High Resolution Imaging Radar for Self-Driving Car
- RF Sensing for Assisted Living and Remote Patient Monitoring
- American Sign Language (ASL) Recognition
- Statistical Signal and Array Processing
- Cognitive Radar
- Adaptive Beamforming
- Massive MIMO and Intelligent Reflecting Surfaces (IRSs) for 6G and Beyond
- Sparse Arrays • Sparse Sampling
- Target Localization and Tracking
- Convex Optimization
- Machine learning
My technical expertise is in the application of fiber-reinforced polymers (FRP) in concrete structures and precast sandwich panels. I'm an expert with nonlinear finite element analysis methods for ductile and brittle materials utilizing such software as ABAQUS. Past and current research is in the fields of static, creep and dynamic (blast) analyses of concrete structures.
I am interested in the research and development of bearing systems, seals, and dampers that will lead to energy efficiency and other improvements of turbomachinery. I am especially interested in compliant foil bearings and the applications where they can provide a major technological leap, such as oil-free propulsion, small turbomachinery, and ultra-high-speed micro-turbines for distributed power generation systems.
Another related area of interest is the development of innovative rotor supports for high-speed kinetic energy storage devices (flywheels).
My research interests include municipal waste engineering, management environmental assessment, evaluation of public communication, and education of environmental issues.
The Widener University School of Engineering Solid Waste Project publishes The Journal of Solid Waste Technology and Management (JSWTM), an international peer-reviewed journal covering landfill, recycling, waste-to-energy, waste reduction, policy and economics, composting, waste collection and transfer, municipal waste, industrial waste, residual waste and other waste management and technology subjects.
JSWTM, ISSN: 1088-1697, is published quarterly (February, May, August, November).
It is abstracted/indexed in: CAS database (Chemical Abstracts), Engineering Abstracts (Compendex), Environmental Abstracts, Environmental Periodicals Bibliography, Pollution Abstracts, All-Russian Institute of Scientific and Technical Information (VINITI, REFERATIVNYI ZHURNAL ), SCOPUS, Google scholar, EBSCO, SCImago and GreenFILE.
The International Conference on Solid Waste Technology and Management (ICSW) is an annual conference where researchers, educators, government officials, consultants, managers, community leaders and others meet to present and discuss topics related to all aspects of solid waste technology and management.
The 33rd International Conference on Solid Waste Technology and Management will be held March 11-14, 2018, in Annapolis, Maryland.
My research is focused on the computational and experimental analysis of physiological systems, particularly the gastrointestinal system. I am currently working on an interinstitutional project developing patient-specific computer models of oropharyngeal swallowing to aid clinicians in developing therapeutic strategies for individuals with swallowing disorders.
My research interests are in the area of mathematical modeling, simulation, optimization, and control of multiscale physico-chemical process systems and in the area of thermodynamic modeling and molecular simulation (Monte Carlo, molecular dynamics and kinetic Monte Carlo) of complex fluids.
My specific research areas include: modeling and simulation of multiscale process systems Detailed process description using conservation laws and stochastic model construction Parameter estimation from microscopic/mesoscopic simulations; model-based control and optimization of multiscale process systems Model reduction, coarse-graining, and predictive control of distributed parameter systems Dynamic optimization over multiple length scales; molecular simulation of complex fluids Monte Carlo, molecular dynamics, and kinetic Monte Carlo methods Development and optimization techniques for parallel codes using domain decomposition.
My long-term research interest and goal is to establish an active, externally-funded research program at Widener University with the motto of "Better health through discovery, de novo design, and effective delivery of novel drugs." Despite tremendous medical advances, we still face many health challenges for which there is no effective cure. The age-associated disorders like cancer and Alzheimer's disease are two of the most notorious examples of such devastating diseases.
Cancer is still the second leading cause of death in the U.S. Similarly, there are currently 5.2 million Alzheimer's disease patients in the U.S., and the numbers are expected to rise significantly owing to the aging population of baby boomers and lack of any effective cure. In this context, the primary aim of my research work is to unravel the molecular mechanisms underlying these diseases and use these novel mechanistic understandings to discover and design effective therapeutics against these traditionally-challenging diseases:
Alzheimer's Disease – Apolipoprotein E (ApoE) is one of the most significant risk factors for late-onset or sporadic Alzheimer's disease. ApoE has been shown to be critical in clearing the harmful ApoE deposits from the brain and its ability to do that depends upon its lipidation status. Therefore, there is a growing interest in understanding the underlying mechanisms involved in ApoE lipidation and using these mechanistic understandings to discover drugs to enhance ApoE lipidation status.
My laboratory is investigating potential involvement of abnormal glucose metabolism in poor ApoE lipidation.
Cancer – The p53 protein plays a central role in protecting cells against carcinogenesis. It is inhibited in 50% of human tumors, however, by interaction with the oncogenic MDM2 protein. Therefore, blocking the p53-binding pocket on MDM2 protein by small-molecule drugs, leading to activation of the tumor suppressor p53 protein presents a fundamentally novel strategy against several types of cancers. In this regard, my laboratory is involved in discovery and design of novel molecules that can mimic the p53 structural features involved in binding to the MDM2 pocket with the ultimate aim of blocking p53-MDM2 interaction.